منابع مشابه
Transcribing through the nucleosome.
The packaging of DNA into chromatin limits sequence accessibility, which affects all DNA-based processes including transcription. Indeed, the fundamental unit of chromatin, the nucleosome, presents a strong barrier to transcription in vitro. Since the discovery of the nucleosome barrier, the question of how the RNA polymerase II (Pol II) machinery overcomes nucleosomes at high speeds in vivo ha...
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The enzymes which transcribe DNA synthesizing RNA (DNA-dependent RNA polymerases) have structural differences in eukaryotic and prokaryotic cells, as indicated by the fact, among others, that there are substances which inhibit their function selectively in prokaryotic cells (streptolydigin and the ansa antibiotics, such as rifamycins and streptovaricin) and in eukaryotic cells (-amanitin). Ansa...
متن کاملTranscribing radio news
We have recently extended the capabilities of BBN's large vocabulary discrete-utterance speech recognition system (BYBLOS) to operate on raw audio recordings of radio news programming. The recordings are given to the system as large monolithic waveforms without any additional sideinformation. Our goal is to transcribe all speech in the input with the highest accuracy possible. The problem is ve...
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The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.
متن کاملTranscribing with Annotation Graphs
Transcriber is a tool for manual annotation of large speech files. It was originally designed for the broadcast news transcription task. The annotation file format was derived from previous formats used for this task, and many related features were hard-coded. In this paper we present a generalization of the tool based on the annotation graph formalism, and on a more modular design. This will a...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/461185a